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Oligo Synthesis

Oligo Synthesis : Supports, CPGs

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Glen UnySupport 1500Å HybridCPG

Glen UnySupport 1500Å HybridCPG

Glen Research

Description

Glen UnySupport 1500Å HybridCPG

Structure

Catalog Number: 28-5040-xx

Description: Glen UnySupport 1500Å HybridCPG






Diluent: Not Applicable
Coupling: This support should be used in a manner identical to normal protected nucleoside support since it contains the DMT group.
Deprotection: See Technical Bulletin for details (Technical Bulletin). Note: This product is not compatible with cyanoethyl protecting group removal protocols using hindered bases such as DEA or DBU. Removal of the cyanoethyl groups prior to cleavage will prevent the release of the oligonucleotide from the support.
Storage: Refrigerated storage, maximum of 2-8°C, dry
Stability in Solution: Not applicable
Please Note: This product is covered by US Patent No.: 6,770,754.

GLEN UNYSUPPORT

Our original Universal Support (20-5000) has been discontinued since complete dephosphorylation using ammonium hydroxide, AMA and anhydrous methylamine gas takes longer than most companies wish to allocate. A recent development has been the use of a support based on a molecule which is “conformationally preorganized” to accelerate the dephosphorylation reaction.1,2 By using a rigid bicyclic molecule on the support, it was hoped that the molecule’s conformation would facilitate the formation of the cyclic phosphate transition state, thereby stimulating the rate of dephosphorylation. It was found that the rate of elimination is markedly faster than the original Universal Support.

The structure of Glen UnySupport is shown below. The N-phenyl version, developed at Isis Pharmaceuticals as UnyLinker™, is available from several companies for large scale oligo synthesis. Glen UnySupport is the N-methyl version, which is preferred for high throughput oligonucleotide synthesis since methylamine rather than aniline is formed on deprotection. We are happy to offer Glen UnySupport in a variety of popular formats under license from Isis Pharmaceuticals.

If you cannot find the answer to your problem then please contact us or telephone +44 (0)1954 210 200

Protocols

Material Safety Data Sheet

Glen Report 24.2: New Products: Universal HybridCPG™ Solid Supports

If you cannot find the answer to your problem then please contact us or telephone +44 (0)1954 210 200

Related products

If you cannot find the answer to your problem then please contact us or telephone +44 (0)1954 210 200