Oligonucleotides containing a bromo or iodo group are prepared conventionally with the exception that deprotection is carried out in ammonium hydroxide at room temperature for 24 hours. Under these conditions, degradation of the halogen group was less than 2%.
Frequently Asked Technical Question
QUESTION: What are the extinction coefficients for propynyl-dC and dU? Also Halogenated dC and dU derivatives? Others?
RESPONSE:See: Table of Extinction Coefficients
B. Froehler, Gilead
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