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PDA Amino Modifiers Improved stability, handling, and deprotection compatibility

Thursday, 8 October 2020

Phosphoramidites are very stable products and generally require no special protection even for summer shipping. One significant exception is amino modifiers with trifluoroacetyl (TFA) protecting groups. These products are inexpensive, easy to use, and industry standards. However, as a viscous oil, they are not very stable and subject to degradation, particularly during shipping.

Phthalic diamide (PDA) amino modifiers are analogous to their TFA counterparts—with one significant contrasting property—they are granular powders. This important property allows for straightforward handling, storage, and aliquoting and leads to a significant increase in stability. Unique to Glen Research, PDA amino-modifiers are fully stable even for extended summer shipping.

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Article Source: Glen Research