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In Vitro Toxicology

In Vitro Toxicology: Mutagenicity kits

The Ames II / Ames MPF Microfluctuation Assays are all modifications of the traditional Ames plate incorporation assay.

The Ames II assay uses the S. typhimurium strains TA98 and TAMix (a mixture of 6 strains, each detecting a specific base-pair substitution), whereas the Ames MPF® kits are available with the strains TA98, TA100, TA1535, TA1537, E.coli WP2 uvrA or E.coli WP2 pKM101.

 

Benefits of Xenometrix Ames Mutagenicity Assays over traditional Ames Procedures

  • Easy, compact and high throughput liquid format with 384 well plates.

  • Simple detection method with easy "readout" (as compared to the traditional assay)

  • Kits include all five types strains cited in OECD 471 (CoA supplied), quality controlled according to the same guideline 

  • Much less  test compound required.  (10 mg per strain if tested in triplicates, +/- S9, 6 semi-logarithmic compound dilutions)

  • Ames MPF is the preferred system for genotoxic impurities due to its low consumption of compound

  • Significantly less consumption of S9

  • Less environmental pollution due to significantly less "contaminated" waste

  • Less user intervention

  • Download presentation 

Ames - Liquid E.coli Strains

Liquid strains for Ames Test Kits

Xenometrix AG

Catalogue No.DescriptionPack SizePriceQty
  • Change to:
  • £
XPSS-0119 E.coliWP2 uvrA[pKM101] (New)50ul €152.40 Quantity Add to Order

Description

Shipping: dry ice / Storage: -70°C

 

New E.coli tester strain

 Xenometrix offers a new strain, the 

E.coliWP2 uvrA[pKM101] in the Ames Microplate Fluctuation Ames MPF assay format which can be used alternatively to the current E.coli Combo strains.

 

Specifications:

  • 50µL semi-solid format, dissolved in 200uL medium
  • Quality controlled

Detailed instructions for use

If you cannot find the answer to your problem then please contact us or telephone +44 (0)1954 210 200