Mutagenicity, cytotoxicity and endocrine disruptor assays.
Mutagenicity Kits- Identify mutagenic compounds
This section contains reagents and kits manufactured by Xenometrix used for identifying a wide variety of chemicals, and products for their genotoxic/mutagenic effects using Ames microfluctuation technology. Kits include those such as Ames II, Ames MPF PENTA 1 and Ames MPF PENTA 2, Ames MPF 1535, etc. The tests come as a complete kit, are standardized and quality controlled. They are run in a liquid format on 384 well plates. The assay system is a microsystems listed in the ICH M7 guideline and it is a version of the Ames fluctuation test cited in the OECD / FDA guidelines. Several publications showing a high concordance with the agar plate method are available. Xenometrix also offers all accessories to perform the Ames assay, such as S9, positive controls, S9 Cofactor solution, etc.
Endocrine Disruptors - In vitro Estrogen and Androgen Activity
Another product range is the “XenoScreen YES/YAS” and “Xenoscreen XL YES YAS” for the detection of substances activating or inhibiting human estrogen and androgen receptors, via agonistic or antagonistic action.
Single and multiple endpoint cytotoxicity assays covering a wide range of mechanisms and read-outs. The test kits are typically used in the early screening phase to determine cytotoxicity endpoints in eukaryotic cells. Xenometrix is the only company offering 4-endpoint cytotoxicity assays