Description
Psoralen
C2 at the 5’-terminus of an oligonucleotide serves effectively as a
cross-linking reagent in double-stranded oligonucleotides. The 6 atom
spacer arm of Psoralen C6 allows cross-linking with a triplex
oligonucleotide strand. Click Chemistry with psoralen azide and one of
our many nucleosidic and non-nucleosidic alkyne derivatives has the
potential to generate a variety of practical cross-linkers. The well
known reversible cross-linking behavior of psoralen with an adjacent
thymidine residue could be very useful.
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