Oligo Synthesis

Oligo Synthesis : CEPs

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dW-CE Phosphoramidite product image

dW-CE Phosphoramidite

dW-CE Phosphoramidite 3-Methyl-2-pivaloyloxy-5-[2'-deoxy-3'-O-(2-cyanoethyl-N,N-diisopropylamino)-phosphino-5'-O-(dimethoxytrityl)-beta-D-ribofuranos-1'-yl]-6-(triisopropylsilylethynyl)-pyridine

Glen Research

Catalogue No.	Description	Pack Size	Price	Qty	Change to:
10-1527-02	dW-CE Phosphoramidite	250 mg	£1,591.00	Quantity	Add
10-1527-90	dW-CE Phosphoramidite	100 umole	£636.00	Quantity	Add
10-1527-95	dW-CE Phosphoramidite	50 umole	£318.00	Quantity	Add

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dW is a C-nucleoside that acts as a strong adenine base paring analog. In addition to the typical two hydrogen bonds found between T and A, dW can also interact with A via van der Waals forces. The result is a dW–A interaction that approaches the strength of a C–G base pair while also exhibiting enhanced base-pairing fidelity. dW can be used in place of T as a single substitution or a complete replacement for oligonucleotide hybridization applications. Please see Glen Report article 31.21 and Glen Report article 31.22 for more details.

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Technical documents here (links to supplier's website)

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J. SantaLucia, Jr.; H.T. Allawi; P. A. Seneviratne, Biochemistry, 1996, 35, 3555-3562.
R. Kierzek; M.E. Burkard; D.H. Turner, Biochemistry, 1999, 38, 14214-14223.
C. Ahlborn, K. Siegmund, C. Richert, J. Am. Chem. Soc., 2007, 129, 15218-15232.
E.T. Kool; J.C. Morales; K.M. Guckian, Angew. Chem. Int. Ed. Engl., 2000, 39, 990-1009.
N. Griesang; C. Richert, Tetrahedron Lett., 2002, 43, 8755-8758.
S. Moran; R.X. Ren; S. Rumney; E.T. Kool, J. Am. Chem. Soc., 1997, 119, 2056-2057.
M. Minuth; C. Richert, Angew. Chem. Int. Ed., 2013, 52, 10874-10877.
T.J. Walter; C. Richert, Nucleic Acids Res., 2018, 46, 8069-8078.
R.W. Wagner; M. D. Matteucci; J.G. Lewis; A.J. Gutierrez; C. Moulds, B.C. Froehler, Science, 1993, 260, 1510-1513.

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Product Specifications

Formula: C57H78N3O8PSi

M.W.: 992.30

F.W.: 311.23

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Coupling: A 15 minute coupling time is recommended. Deblocking should be carried out with 3% dichloroacetic acid in dichloromethane. Deprotection: Deprotection must be carried out in the absence of heat.
Otherwise, all standard conditions should be compatible. Typical conditions would be ammonium hydroxide or ammonium hydroxide/aqueous methylamine 1:1 at room temperature.

If you cannot find the answer to your problem then please contact us or telephone +44 (0)1954 210 200

If you cannot find the answer to your problem then please contact us or telephone +44 (0)1954 210 200