| 5-Me-U-CE Phosphoramidite |
Catalog Number: 10-3050-xx
Description: 5-Me-U-CE Phosphoramidite
5'-Dimethoxytrityl-5-Methyl-Uridine, 2'-O-TBDMS-3'-[(2-cyanoethyl)-
(N,N-diisopropyl)]-phosphoramidite |
| Formula: C46H63N4O9PSi |
M.W.: 875.08 |
F.W.: 320.19 |
minor rna phosphoramidites (TBDMS PROTECTED)
Inosine and 5-Methyl-Uridine are useful for analyzing RNA structure and activity relationships. 5-Bromo-Uridine and 5-Iodo-Uridine have been used for crystallography studies and cross-linking experiments. 6-Thioguanosine (6-thio-G) has applications in ribozyme and siRNA research, as well as in RNA-protein interactions. The removal of the silyl protecting group without interfering with the sulfur is critical. This is removed1 cleanly by triethylamine trihydrofluoride in DMSO but t-butylammonium fluoride (TBAF) leads to degradation of the thio-nucleotide analogue and should not be used. 2-Aminopurine riboside is useful for analyzing RNA structure and activity relationships, for example, in ribozyme studies.
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