Crystallins are composed of two gene products; alpha-A and alpha-B, for
acidic and basic, respectively. Alpha crystallins can be induced by heat
shock and are members of the small heat shock protein(sHSP also known
as the HSP20). They act as molecular chaperones and hold them in in
large soluble aggregates. These heterogeneous aggregates consist of
30-40 subunits; the alpha-A and alpha-B subunits have a 3:1 ratio,
respectively.
Two additional function of '-crystallins are an autokinase
activity and participation in the intracellular architecture. Alpha-B
is expressed widely in many tissues and organs and occurs in many
neurological diseases. This aptamer was selected by scientists at Base
Pair Biotechnologies using proprietary methods and Crystallin AB, Novus
Biologicals [Cat #NBC1-18352]? as a target.
Target: Crystallin alpha B
Target Species: human
Target Type: protein
Affinity Constant (Kd): 152 nM
Default 3' Linker (Spacer) is 10T. Please submit a custom quote request for other options.
Datasheet
0.1uM synthesis scale (20-200ug)
Please choose your modification and add as an extra catalogue number:
ATWUNMOD - Unmodified
ATWAMINE - Amine modification
ATWBIOTIN - Biotin modification
ATWTHIOL - Thiol modification (extra charge)
ATWFLUOR - Fluor (all) modification (extra charge)
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