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Aptamers

Aptamers: Catalogue Aptamers

Important information

Do you know what modifications you will need for your aptamers?  see "modifications" section for details

Cytomegalovirus pp65 aptamer

Cytomegalovirus pp65 ATW0058

Base Pair Bio

Catalogue No.DescriptionPack SizePriceQty
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  • £
ATW0058-100Cytomegalovirus pp6510 AEU (100ug) POA Quantity Add to Order
ATW0058-25Cytomegalovirus pp652.5 AEU (25ug) POA Quantity Add to Order

Description

Human cytomegalovirus, HCMV, is a herpes virus that infects between 50 to 85% of adults by the age of 50. Though most people do not show symptoms of disease, HCMV is a major cause of morbidity in AIDS and organ transplant. There is currently no vaccine and no cure for HCMV. Pp65 is the primary protein invlolved in evasion of host immune response in HCMV infection. It has been shown to prevent recognition by the immune system, to interfere with synthesis of immune components, and to inhibit natural killer cell cytotoxicity.

Target:   CMV pp65 (Cytomegalovirus pp65)

Target Species:   viral

Target Type:   protein

Affinity Constant (Kd):   64 nM

Default 3' Linker (Spacer) is 10T. Please submit a custom quote request for other options.

Datasheet

0.1uM synthesis scale (20-200ug)
Please choose your modification and add as an extra catalogue number:
ATWUNMOD - Unmodified
ATWAMINE - Amine modification
ATWBIOTIN - Biotin modification
ATWTHIOL - Thiol modification (extra charge)
ATWFLUOR - Fluor (all) modification (extra charge)

 

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Protocols

Datasheet

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References

John Paul Tomtishen III, (2012) Human cytomegalovirus tegument proteins (pp65, pp71, pp150, pp28). Virology Journal. 9:22.

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Notes

Please note that aptamers have much lower molecular weights than antibodies. Thus, there are typically five to fifteen times as many moles or molecules of aptamers present in a solution containing an equal mass. For example, 100 micrograms of an aptamer is equivalent to 0.5 to 1.5 mg of antibody, depending on the particular aptamer.

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Related products

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