Zika virus is a mosquito-borne flavivirus. It is transmitted by the
Aedes mosquito, which also transmits Dengue, Chikungunya, and yellow
fever. Contraction of Zika during pregnancy can cause microcephaly and
other abnormalities in newborns as well as fetal loss, stillbirth, and
pre-term birth. Zika infection has also been linked to Guillain-Barre
syndrome, neuropathy, and myelitis (1). This DNA aptamer was selected
against the Zika envelope protein in mosquito saliva, but has also been
shown to bind the Zika envelope protein in serum and defibrinated blood
(2).
- WHO. https://www.who.int/news-room/fact-sheets/detail/zika-virus. Accessed May 15, 2019.
- Saraf, N., et al. Multiplex viral detection platform based on a aptamers-integrated microfluidic channel. ACS Omega. 2019. 4:2234-2240.
Target: Zika
Target Species: viral
Target Type: protein
Affinity Constant (Kd): 2.2 nM
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