2’-OMe-Thiophosphoramidites
The phosphorodithioate linkage (PS2) is both achiral and essentially resistant to nucleases. Previous studies have shown very interesting results which include observations that DNA with PS2 linkages activates RNase H , strongly inhibits human immunodeficiency virus (HIV) reverse transcriptase, induces β-cell proliferation and differentiation, and is completely resistant to hydrolysis by various nucleases. 2'-OMe- RNA Thiophosphoramidites are RNA monomers designed to produce oligos combining the PS2 linkage with the 2'-O-methyl ribose modification. These PS2-modified RNA oligos have potential for use in siRNAs and dithiophosphate aptamers (thioaptamers).
![2’-OMe-C-Thiophosphoramidite 2’-OMe-C-Thiophosphoramidite](/library/images/html_images/Glen_structures/2-OMe-C-Thiophosphoramidite.gif)
![2’-OMe-U-Thiophosphoramidite 2’-OMe-U-Thiophosphoramidite](/library/images/html_images/Glen_structures/2-OMe-U-Thiophosphoramidite.gif)
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