Hemophilia Genetics Lab: X-linked Inheritance
In this engaging case study, students test a fictional family for an
X-linked hemophilia mutation.
Baby Andrew was just diagnosed with
hemophilia. Students will use gel electrophoresis to determine whether
Andrew’s female relatives carry the same X-linked mutation. Explore
non-Mendelian inheritance with a hands-on experiment!
- Techniques: Micropipetting, gel electrophoresis
- Topics: Human genetics, biomedical science, non-Mendelian inheritance
- Time required: Can be completed in one 45-minute class period
- Level: General high school through college
See video here
What is included?
DNA samples for 8 lab groups:
- 4 Simulated human DNA samples
- Fast DNA Ladder 1
Storage notes:
- If kept in the freezer, reagents can be stored for 12 months after receipt.
- If kept in the refrigerator, reagents can be stored for 6 months after receipt.
Required equipment:
Gel electrophoresis reagents and plastic tubes are supplied by the user
- Agarose
- Gel electrophoresis buffer (e.g. TBE)
- Fluorescent DNA stain (e.g. SeeGreen™ or GelGreen®)
- Plastic tubes for distributing samples to student groups
The Learning Lab Companion Kit (KT-1510-01) provides sufficient reagents to prepare and run eight gels when using the blueGel electrophoresis system, as well as plastic tubes to distribute samples to student groups.
Storage notes:
- If kept in the freezer, reagents can be stored for 12 months after receipt.
- If kept in the refrigerator, reagents can be stored for 6 months after receipt.
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