ERK2 (Mitogen-activated protein kinase 1, also known
as MAPK1, p42MAPK, and ERK2) is a member of the MAP kinase family. MAP
kinases, also known as extracellular signal-regulated kinases (ERKs),
act as an integration point for multiple biochemical signals, and are
involved in a wide variety of cellular processes such as proliferation,
differentiation, transcription regulation and development. The
activation of this kinase requires its phosphorylation by upstream
kinases.
This
aptamer was selected by scientists at Base Pair Biotechnologies using
proprietary methods and phosphorylated 183 ERK2 (aa 171-189) peptide
CVADPDHDHTGFL(t)EYVATR as a target
Target: ERK2 (aa171-189) Phospho aa183
Target Species: multi-species
Target Type: peptide
Dissociation Constant (Kd): 7.7 nM
Default 3' Linker (Spacer) is 10T. Please submit a custom quote request for other options.
*Please note that aptamers have much lower molecular weights than antibodies. Thus, there are typically five to fifteen times as many moles or molecules of aptamers present in a solution containing an equal mass. For example, 100 micrograms of an aptamer is equivalent to 0.5 to 1.5 mg of antibody, depending on the particular aptamer.
Image courtesy of Ctr for Study of Systems Biology at Georgia Tech
Datasheet
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