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Oligo Synthesis

Oligo Synthesis : CEPs

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5'-TCO C6 Phosphoramidite

Transcyclooctene (TCO) is a strained alkene that reacts with tetrazine labels in an inverse-electron-demand Diels-Alder cycloaddition (IEDDA) reaction. TCO-tetrazine ligation is ultrafast, selective, and has long-term stability in aqueous solutions...

Glen Research

Catalogue No.DescriptionPack SizePriceQty
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10-1943-025'-TCO C6 Phosphoramidite0.25g €1,309.20 Quantity Add to Order
10-1943-90 5'-TCO C6 Phosphoramidite100 umol €260.40 Quantity Add to Order
10-1943-955'-TCO C6 Phosphoramidite50 umol €152.40 Quantity Add to Order

Description

Description

6-(4-E-cycloocten-1-yl-oxyamido)-hexyl-(2-cyanoethyl)- (N,N-diisopropyl)-phosphoramidite

Transcyclooctene (TCO) is a strained alkene that reacts with tetrazine labels in an inverse-electron-demand Diels-Alder cycloaddition (IEDDA) reaction. TCO-tetrazine ligation is ultrafast, selective, and has long-term stability in aqueous solutions. This is a 5'-modifier only and is compatible with a single oxidation cycle with 0.02M iodine.

 

Product Specifications

 

Formula:C24H44N3O4P
M.W.:469.61
F.W.:331.35

 

Details

Usage

  • Coupling: 3 minute coupling time recommended.
  • Deprotection: Ammonium hydroxide for 2 hr at 65°C or as required by nucleobases.
Specifications
Diluent Anhydrous Acetonitrile
Storage Freezer storage; -10 to -30°C, dry
Stability 1-2 Days

Dilution/Coupling Data

The table below show pack size data and, for solutions, dilution and approximate coupling based on normal priming procedures.

ABI 392/394


Technical Documents

Safety Data Sheet (EU)

Safety Data Sheet (Other)

Glen Report 36-24: New Products Catalyst-free Click Reactions

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