Applications

Oligo Synthesis : CEPs

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2’-OMe-Thiophosphoramidites

Glen Research

Catalogue No.	Description	Pack Size	Price	Qty	Change to: €
10-3170-02	2'-OMe-A-Thiophosphoramidite	0.25g	£655.00	Quantity	Add to Order
10-3170-90	2'-OMe-A-Thiophosphoramidite	100umole	£273.00	Quantity	Add to Order
10-3171-02	2’-OMe-C-Thiophosphoramidite	0.25g	£655.00	Quantity	Add to Order
10-3171-90	2’-OMe-C-Thiophosphoramidite	100umole	£273.00	Quantity	Add to Order
10-3172-02	2’-OMe-G-Thiophosphoramidite	0.25g	£655.00	Quantity	Add to Order
10-3172-90	2’-OMe-G-Thiophosphoramidite	100umole	£273.00	Quantity	Add to Order
10-3173-02	2’-OMe-U-Thiophosphoramidite	0.25g	£655.00	Quantity	Add to Order
10-3173-90	2’-OMe-U-Thiophosphoramidite	100umole	£273.00	Quantity	Add to Order

Description

2’-OMe-Thiophosphoramidites

The phosphorodithioate linkage (PS2) is both achiral and essentially resistant to nucleases. Previous studies have shown very interesting results which include observations that DNA with PS2 linkages activates RNase H , strongly inhibits human immunodeficiency virus (HIV) reverse transcriptase, induces β-cell proliferation and differentiation, and is completely resistant to hydrolysis by various nucleases. 2'-OMe- RNA Thiophosphoramidites are RNA monomers designed to produce oligos combining the PS2 linkage with the 2'-O-methyl ribose modification. These PS2-modified RNA oligos have potential for use in siRNAs and dithiophosphate aptamers (thioaptamers).

2'-OMe-A-Thiophosphoramidite 2’-OMe-C-Thiophosphoramidite