NTRK3 Break Apart FISH Probe Kit
The NTRK3 Break Apart FISH Probe Kit is designed to detect rearrangements in the human NTRK3 gene
located on chromosome band 15q25.3. In addition to revealing breaks, which can lead to translocation of parts
of the gene, inversion, or its fusion to other genes, the probe set can also be used to identify other NTRK3
aberrations such as deletions or amplifications. Rearrangements and abnormal expression of the NTRK3 gene
– also known as TRKC, GP145-TrkC or gp145(trkC) – has been observed in medulloblastoma, fibrosarcoma,
nephroma, some breast carcinoma subtypes and other malignancies.
LSP NTRK3 5’ FISH Probe covers the 5’ (start) portion of the NTRK3 gene and some adjacent genomic
sequences. LSP NTRK3 3‘ FISH Probe covers sequences at the 3’ (end) of the gene and some downstream sequences. The two probes are flanking sequences across the NTRK3 gene in which variable breakpoints have been observed.
Signal Pattern Interpretation
Normal Patterns
| Abnormal Patterns |
| 2F* | Other Patterns |
*Overlapping orange and green signals can appear as yellow.
REFERENCES
1) Makretsov N, et al. Genes Chromosomes Cancer. 40(2):152-7 (2004).
2) Kralik JM, et al. Diagn Pathol. 6:19 (2011).
3) Knezevich SR, et al. Nat. Genet. 18(2):184-7 (1998)
4) Vokuhl C, et al. Pediatr. Blood Cancer. 65(4): doi: 10.1002/pbc.26925 (2018).
5) Chiang S, et al. Am. J. Surg. Pathol. 42(6):791-798 (2018)
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