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Oligo Synthesis

Oligo Synthesis : CEPs

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Ac-5-Me-C-LA-CE Phosphoramidite

5'-Dimethoxytrityl-N-acetyl-5-methyl-(2'-O, 4'-C methylene)-Cytidine,3'-[(2-cyanoethyl)-(N,N-diisopropyl)]-phosphoramidite

Glen Research

Catalogue No.DescriptionPack SizePriceQty
10-2015-02Ac-5-Me-C-LA-CE Phosphoramidite0.25g £95.00 Quantity Add to Order
10-2015-05Ac-5-Me-C-LA-CE Phosphoramidite0.5g £186.00 Quantity Add to Order

Description

Locked Nucleic Acid (LNA) is a modified ribonucleic acid containing a methylene bridge connecting the 2'-oxygen and 4'-carbon atoms. Ac-5-Me-C-LA-CE Phosphoramidite incorporates 5-methylcytosine in place of standard cytosine, a modification that plays a critical role in therapeutic applications. This version of C-LNA features an acetyl (Ac) protecting group, making it compatible with UltraFast deprotection using AMA.

Product Specifications

Formula: C43H52N5O9P
M.W.: 813.89
F.W.: 331.22
CAS Number: NA

 

 

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References

SDS and CoA available via manufacturer's website here

References

  • The Glen Report, 2014, 26.1, 4-6. K.
  • Kariko, M. Buckstein, H. Ni, and D. Weissman, Immunity, 2005, 23, 165-175.

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Notes

Specifications

  • Diluent Anhydrous Acetonitrile
  • Recommended Storage Freezer storage; -10 to -30°C, dry
  • Stability In Solution 1-2 Days

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Applications & Benefits

Usage

Coupling: Coupling: 3 minute coupling time recommended. Increase oxidation time 3 fold for optimal performance. Deprotection: Deprotection: No changes needed from standard method recommended by synthesizer manufacturer.

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