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Oligo Synthesis

Oligo Synthesis : Click Chemistry

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DBCO-sulfo-NHS Ester

DBCO-sulfo-NHS Ester

Glen Research

Catalogue No.DescriptionPack SizePriceQty
50-1941-23DBCO-sulfo-NHS Ester5.2mg £70.00£66.50Offer until : 31-Aug-2020Offer Code : GLEN55% off all Glen products View Offer Quantity Add to Order
50-1941-24DBCO-sulfo-NHS Ester52mg £240.00£228.00Offer until : 31-Aug-2020Offer Code : GLEN55% off all Glen products View Offer Quantity Add to Order

DBCO-sulfo-NHS Ester

DBCO-sulfo-NHS Ester

Glen Research

DBCO-sulfo-NHS Ester

Structure

 

Catalog Number: 50-1941-xx

Description: DBCO-sulfo-NHS Ester

6-oxo-6-(dibenzo[b,f]azacyclooct-4-yn-1-yl)-caproic acid sulfo-
N-hydroxysuccinimide ester, sodium salt
Formula: C25H21N2NaO8S M.W.: 532.50 F.W.: 316.37



Storage: Storage: Freezer storage, -10 to -30°C, dry
Stability in Solution: n/a

COPPER-FREE CLICK CHEMISTRY

At Glen Research, our goal was to offer a copper-free click phosphoramidite reagent with the following properties:

  • Simple to use
  • Stable in solution on the synthesizer
  • Stable to ammonium hydroxide and AMA
  • Excellent click performance in 17 hours or less at room temperature

From the variety of cyclooctyne-based copper-free click reagents so far described, we have chosen to offer compounds based on a dibenzo-cyclooctyne (DBCO) structure. We are offering 5’-DBCO-TEG Phosphoramidite for preparing oligos with a 5’-DBCO modification and DBCO-dT-CE Phosphoramidite for inserting a DBCO group at any position within the oligonucleotide. DBCO-sulfo-NHS Ester is also offered for post-synthesis conjugation reactions. DBCO-modified oligos may be conjugated with azides in organic solvents, such as DMSO, or aqeous buffers. Depending on the azide used, the reaction will go to completion in 4-17 hours at room temperature. Simple desalting on a Glen Gel-Pak™ leads to a product with virtually quantitative conjugation efficiency.

If you cannot find the answer to your problem below then please contact us or telephone 01954 210 200

DBCO-sulfo-NHS Ester

DBCO-sulfo-NHS Ester

Glen Research

Material Safety Data Sheet

?Glen Report 24.1: New Product - Dibenzocyclooctyl (DBCO) Copper-Free Click Chemistry

If you cannot find the answer to your problem below then please contact us or telephone 01954 210 200