Cambio - Excellence in Molecular Biology

Oligo Synthesis

Oligo Synthesis : RNA synthesis

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For multiples of the same product please request a quote.

Some of Glen's products are hazardous and may be subject to additional shipping charges.

Full product information is available on Glen Research's web site.

1-Methyl-PseudoUridine Phosphoramidite

1-Methyl-PseudoUridine Phosphoramidite

Glen Research

Catalogue No.DescriptionPack SizePriceQty
10-3056-021-Methyl-PseudoUridine Phosphoramidite0.25g £1,840.00£1,564.00Offer until : 30-Sep-2019Offer Code : GLEN1515% offer orders over £1000 View Offer Quantity Add to Order
10-3056-901-Methyl-PseudoUridine Phosphoramidite100umole £656.00£557.60Offer until : 30-Sep-2019Offer Code : GLEN1515% offer orders over £1000 View Offer Quantity Add to Order
10-3056-951-Methyl-PseudoUridine Phosphoramidite50umole £336.00£285.60Offer until : 30-Sep-2019Offer Code : GLEN1515% offer orders over £1000 View Offer Quantity Add to Order

1-Methyl-PseudoUridine Phosphoramidite

1-Methyl-PseudoUridine Phosphoramidite

Glen Research

1-Methyl-PseudoUridine Phosphoramidite

5'-Dimethoxytrityl-1-methyl-pseudoUridine, 2'-O-TBDMS-3'-[(2-cyanoethyl)-(N,N-diisopropyl)]-phosphoramidite

1-Methyl-PseudoUridine PhosphoramiditeFormula: C46H63N4O9PSi 
M.W.: 875.07 
F.W.: 320.19
 
RNA methylation occurs in a large selection of RNA nucleosides and this post transcriptional modification of RNA, carried out by a variety of RNA methyltransferases, appears in a wide variety of RNA species - including tRNA, mRNA, miRNA and RNA viruses. Over 90 methylated nucleosides have been found in tRNA and these play many significant roles in tRNA structure. In addition, methylation appears to mark the tRNA as mature, preventing its degradation as well as directing localization within the cell. mRNA, modified with 1-methylpseudouridine (1-Me-Ψ ) alone or in combination with 5-methylcytidine (5-Me-C), significantly increases protein expression in cells and mouse models. 1-Me-Ψ is also a modified nucleobase that can greatly enhance the properties of mRNA by reducing immunogenicity and increasing stability.

If you cannot find the answer to your problem below then please contact us or telephone 01954 210 200

1-Methyl-PseudoUridine Phosphoramidite

1-Methyl-PseudoUridine Phosphoramidite

Glen Research

 

If you cannot find the answer to your problem below then please contact us or telephone 01954 210 200

1-Methyl-PseudoUridine Phosphoramidite

1-Methyl-PseudoUridine Phosphoramidite

Glen Research

Diluent: Anhydrous Acetonitrile

Coupling: 12 minute coupling time recommended.

Deprotection: See Technical Bulletin for details (http://www.glenresearch.com/Technical/TB_RNA_TBDMS_Deprotection.pdf).

Storage: Storage: Freezer storage, -10 to -30°C, dry

Stability in Solution: 1-2 days

If you cannot find the answer to your problem below then please contact us or telephone 01954 210 200