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Oligo Synthesis

Oligo Synthesis : Supports,CPGs

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3'-Thiol-Modifier C3 S-S CPG

3'-Thiol-Modifier C3 S-S CPG

Glen Research

Catalogue No.DescriptionPack SizePriceQty
20-2933-013'-Thiol-Modifier C3 S-S CPG 0.1g £68.00£62.56Offer until : 31-Dec-2019Offer Code : GLEN88% off all Glen Research products View Offer Quantity Add to Order
20-2933-103'-Thiol-Modifier C3 S-S CPG 1.0g £480.00£441.60Offer until : 31-Dec-2019Offer Code : GLEN88% off all Glen Research products View Offer Quantity Add to Order
20-2933-133'-Thiol-Modifier C3 S-S CPG 1x10µm £180.00£165.60Offer until : 31-Dec-2019Offer Code : GLEN88% off all Glen Research products View Offer Quantity Add to Order
20-2933-143'-Thiol-Modifier C3 S-S CPG 1x15µm £280.00£257.60Offer until : 31-Dec-2019Offer Code : GLEN88% off all Glen Research products View Offer Quantity Add to Order
20-2933-413'-Thiol-Modifier C3 S-S CPG 4x1.0µm £100.00£92.00Offer until : 31-Dec-2019Offer Code : GLEN88% off all Glen Research products View Offer Quantity Add to Order
20-2933-423'-Thiol-Modifier C3 S-S CPG 4x0.2µm £60.00£55.20Offer until : 31-Dec-2019Offer Code : GLEN88% off all Glen Research products View Offer Quantity Add to Order

3'-Thiol-Modifier C3 S-S CPG

3'-Thiol-Modifier C3 S-S CPG

Glen Research

3'-Thiol-Modifier C3 S-S CPG

 

Structure

Catalog Number: 20-2933-xx

Description: 3'-Thiol-Modifier C3 S-S CPG

1-O-Dimethoxytrityl-propyl-disulfide,1'-succinyl-lcaa-CPG


F.W.: Reduced FW - 154.12 Unreduced FW - 244.27

Diluent: Not Applicable
Coupling: To avoid oxidative cleavage of the disulfide linkage, all oxidation steps should use 0.02M Iodine solution.
Deprotection: After normal deprotection, the disulfide can be cleaved at room temperature in 30 minutes with 100 mM DTT pH 8.3 - 8.5 in the buffer of your choice. Technical Bulletin
Storage: Freezer storage, -10 to -30°C, dry
Stability in Solution: Not Applicable

The 3’-Thiol-Modifier S-S CPG supports are used to introduce 3’-thiol linkages with three and six carbon spacers in oligonucleotides. DTPA CPG is used to introduce a dithiol group at the 3’-terminus. In conjunction with DTPA Phosphoramidite, it is simple to produce oligonucleotides with multiple thiol groups at the 3’ terminus, which is ideal for conjugation to gold surfaces. With Glyceryl CPG the 3’-terminus of an oligonucleotide is readily oxidized by sodium periodate to form a 3’-phosphoglycaldehyde. The aldehyde may be further oxidized to the corresponding carboxylic acid. Either the aldehyde or the carboxylate may be used for subsequent conjugation to amine-containing products.

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3'-Thiol-Modifier C3 S-S CPG

3'-Thiol-Modifier C3 S-S CPG

Glen Research

MSDS

If you cannot find the answer to your problem below then please contact us or telephone 01954 210 200