Cambio - Excellence in Molecular Biology

Oligo Synthesis

Oligo Synthesis : Supports,CPGs

Prices quoted are for single packs only.

For multiples of the same product please request a quote.

Some of Glen's products are hazardous and may be subject to additional shipping charges.

Full product information is available on Glen Research's web site.

Glen UnySupport™ 1000

Glen UnySupport 1000

Glen Research

Catalogue No.DescriptionPack SizePriceQty
20-5041-01Glen UnySupport™ 1000 0.1g £8.80£8.10Offer until : 31-Dec-2019Offer Code : GLEN88% off all Glen Research products View Offer Quantity Add to Order
20-5041-02Glen UnySupport™ 1000 0.25g £20.00£18.40Offer until : 31-Dec-2019Offer Code : GLEN88% off all Glen Research products View Offer Quantity Add to Order
20-5041-10Glen UnySupport™ 1000 1.0g £76.00£69.92Offer until : 31-Dec-2019Offer Code : GLEN88% off all Glen Research products View Offer Quantity Add to Order
20-5141-13Glen UnySupport™ 1000 pack/1 10umole TWIST format £80.00£73.60Offer until : 31-Dec-2019Offer Code : GLEN88% off all Glen Research products View Offer Quantity Add to Order
20-5141-41Glen UnySupport™ 1000 pack/4 1umole £48.00£44.16Offer until : 31-Dec-2019Offer Code : GLEN88% off all Glen Research products View Offer Quantity Add to Order
20-5141-42Glen UnySupport™ 1000 pack/4 0.2umole £32.00£29.44Offer until : 31-Dec-2019Offer Code : GLEN88% off all Glen Research products View Offer Quantity Add to Order
20-5141-91 96 well formatGlen UnySupport™ 1000 pack/96 1umole £300.00£276.00Offer until : 31-Dec-2019Offer Code : GLEN88% off all Glen Research products View Offer Quantity Add to Order
20-5141-92 96 well formatGlen UnySupport™ 1000 pack/96 200nmole £200.00£184.00Offer until : 31-Dec-2019Offer Code : GLEN88% off all Glen Research products View Offer Quantity Add to Order
20-5141-95 96 well formatGlen UnySupport™ 1000 pack/96 40nmole £200.00£184.00Offer until : 31-Dec-2019Offer Code : GLEN88% off all Glen Research products View Offer Quantity Add to Order
20-5241-14Glen UnySupport™ 1000 Expedite Formatpack/1 15 µmole column (TWIST Format) £120.00£110.40Offer until : 31-Dec-2019Offer Code : GLEN88% off all Glen Research products View Offer Quantity Add to Order
20-5241-41Glen UnySupport™ 1000 Expedite Formatpack/4 1umole £48.00£44.16Offer until : 31-Dec-2019Offer Code : GLEN88% off all Glen Research products View Offer Quantity Add to Order
20-5241-42Glen UnySupport™ 1000 Expedite Formatpack/4 0.2umole £32.00£29.44Offer until : 31-Dec-2019Offer Code : GLEN88% off all Glen Research products View Offer Quantity Add to Order
20-5241-45Glen UnySupport™ 1000 Expedite Formatpack/4 40nmole £32.00£29.44Offer until : 31-Dec-2019Offer Code : GLEN88% off all Glen Research products View Offer Quantity Add to Order
20-5441-95Glen UnySupport™ 1000 96x40nm frits £120.00£110.40Offer until : 31-Dec-2019Offer Code : GLEN88% off all Glen Research products View Offer Quantity Add to Order

Glen UnySupport™ 1000

Glen UnySupport 1000

Glen Research

Glen UnySupport 1000

Structure

Catalog Number: 20-5041-xx

Description: Glen UnySupport 1000

N-Methyl-succinimido[3,4-b]-7-oxabicyclo[2.2.1]heptane-6-(4,4'-dimethoxytrityloxy)-
5-succinoyl long chain alkylamino CPG
     

Diluent: n/a
Coupling: This support should be used in a manner identical to normal protected nucleoside support since it contains the DMT group.
Deprotection: Solution phase: Ammonium Hydroxide:MethylAmine (AMA) 1:1 for 1 hour at 65°C or Ammonium Hydroxide for 8 hours at 55°C. For sensitive minor bases or dyes, Glen UnySupport may be eliminated with 50 mM Potassium Carbonate in Methanol in 17 hours at room temperature or with Tert-Butylamine/water 1:3 (v/v) for 4 hours at 60°C. Gas Phase: Methylamine gas for 30 minutes at 65°C at 30 psi.
Storage: Controlled room temperature or lower, dry
Stability in Solution: Not Applicable
Please Note: This product is covered by patents or patents pending owned by Isis Pharmaceuticals, Inc. ("Isis"). Purchase of this product includes a limited license to use this product solely for internal research. This license specifically excludes (and you have no right to use this product for): (a) therapeutic or diagnostic applications (including products or services that incorporate this product), (b) any in vivo toxicity/safety study in support of an investigational new drug application (or foreign counterpart), (c) resale (including sale of any products or services that incorporate this product) or (d) gene functionalization activities (including products or services that incorporate data derived from gene functionalization activities) if such activities have commercial application, any and all of which require a separate license from Isis. Neither this product nor any product created through its use may be used in human clinical trials.

GLEN UNYSUPPORT

Our original Universal Support (20-5000) has been discontinued since complete dephosphorylation using ammonium hydroxide, AMA and anhydrous methylamine gas takes longer than most companies wish to allocate. A recent development has been the use of a support based on a molecule which is “conformationally preorganized” to accelerate the dephosphorylation reaction.1,2 By using a rigid bicyclic molecule on the support, it was hoped that the molecule’s conformation would facilitate the formation of the cyclic phosphate transition state, thereby stimulating the rate of dephosphorylation. It was found that the rate of elimination is markedly faster than the original Universal Support.

The structure of Glen UnySupport is shown below. The N-phenyl version, developed at Isis Pharmaceuticals as UnyLinker™, is available from several companies for large scale oligo synthesis. Glen UnySupport is the N-methyl version, which is preferred for high throughput oligonucleotide synthesis since methylamine rather than aniline is formed on deprotection. We are happy to offer Glen UnySupport in a variety of popular formats under license from Isis Pharmaceuticals.

If you cannot find the answer to your problem below then please contact us or telephone 01954 210 200

Glen UnySupport™ 1000

Glen UnySupport 1000

Glen Research

Material Safety Data Sheet

Glen Report 20.2: New Universal Support - Glen UnySupport

If you cannot find the answer to your problem below then please contact us or telephone 01954 210 200

Glen UnySupport™ 1000

Glen UnySupport 1000

Glen Research

Glen Report 22.2

  • A.P. Guzaev, and M. Manoharan, J Am Chem Soc, 2003, 125, 2380- 2381.
  • R.K. Kumar, A.P. Guzaev, C. Rentel, and V.T. Ravikumar, Tetrahedron, 2006, 62, 4528.

If you cannot find the answer to your problem below then please contact us or telephone 01954 210 200