Cambio - Excellence in Molecular Biology

Lab Reagents

Lab Reagents: Bioactive proteins

Bioactive Proteins for critical biological studies Medicago's Bioactive Proteins include the calcium-binding protein Calmodulin and other custom-made proteins. The Bioactive Proteins are provided as freeze-dried powders manufactured under aseptic conditions and following GMP procedures. We have extensive experience in the development and manufacturing of proteins. If you don't find the protein you are looking for we can certainly produce it for you. Try us! •Ultrapure quality •Stable and high activity •Contract manufacturing of proteins •Custom purification services .

Calmodulin

Calmodulin is a bioactive protein isolated from bovine testes with a molecular weight of 16,7 kDa. The material is derived from cattle born and raised in Sweden, a country where BSE is non-existing. Calmodulin is a calcium-binding protein expressed in many eukaryotic cells. By binding to and regulating various protein targets, it affects cellular processes such as metabolism, nerve growth, apoptosis, inflammation, muscle contraction and memory.

Medicago AB

Catalogue No.DescriptionPack SizePriceQty
MC-05-0103-1Calmodulin 1 mg £60.00 Quantity Add to Order
MC-05-0103-2Calmodulin 2.5 mg £115.00 Quantity Add to Order

Calmodulin

Calmodulin is a bioactive protein isolated from bovine testes with a molecular weight of 16,7 kDa. The material is derived from cattle born and raised in Sweden, a country where BSE is non-existing. Calmodulin is a calcium-binding protein expressed in many eukaryotic cells. By binding to and regulating various protein targets, it affects cellular processes such as metabolism, nerve growth, apoptosis, inflammation, muscle contraction and memory.

Medicago AB

Product description

Calmodulin is a bioactive protein isolated from bovine testes with a molecular weight of 16,7 kDa. The material is derived from cattle born and raised in Sweden, a country where BSE is non-existing. Calmodulin is a calcium-binding protein expressed in many eukaryotic cells. By binding to and regulating various protein targets, it affects cellular processes such as metabolism, nerve growth, apoptosis, inflammation, muscle contraction and memory.

Many proteins use Calmodulin as a calcium sensor and signal transducer, as the proteins themselves are not able to bind calcium. The molecule can bind a maximum of four calcium ions and by undergoing post-translational modifications such as acetylation, phosphorylation, proteolytic cleavage and methylation, its functions can potentially be altered.

Medicago’s Calmodulin is supplied as a lyophilized white powder or flocculate from 50 mM NH4HCO3 with 10 µM CaCl2. No preservatives are added. The protein content is analyzed by amino acid assay and is never less than 80 % of weighed substance. The material has been subjected to an acid treatment for minimum 30 min. The protein is derived from a single batch and is homogenous.


Features         

  • Calcium-binding protein
  • Intracellular receptor protein
  • Homogenous and highly pure
  • Lyophilized powder

 

 

 

Directions for use

The protein may be reconstituted with 2 ml of deionized water before use. Spin the vial gently until full dissolution. Aggregation is thought to occur in the presence of high concentrations of 2-mercaptoethanol.

 

Shipping and storage

The product is shipped at -20°C however for over-the-day transport it may be shipped at ambient temperature. The lyophilized powder is stable for more than five years from production date when stored below -20°C. After reconstitution with deionized water, the solution may be stored frozen in working aliquots for up to 12 months.

 

If you cannot find the answer to your problem below then please contact us or telephone 01954 210 200

Calmodulin

Calmodulin is a bioactive protein isolated from bovine testes with a molecular weight of 16,7 kDa. The material is derived from cattle born and raised in Sweden, a country where BSE is non-existing. Calmodulin is a calcium-binding protein expressed in many eukaryotic cells. By binding to and regulating various protein targets, it affects cellular processes such as metabolism, nerve growth, apoptosis, inflammation, muscle contraction and memory.

Medicago AB

Specifications

Appearance: White lyophilized powder                                

Source: Bovine testes

Molecular weight: 16.680 kDa

Binding specificity: Calcium

Microorganisms: < 100 CFU/g

Protein content: > 80 %

Identity: SDS-PAGE

If you cannot find the answer to your problem below then please contact us or telephone 01954 210 200

Calmodulin

Calmodulin is a bioactive protein isolated from bovine testes with a molecular weight of 16,7 kDa. The material is derived from cattle born and raised in Sweden, a country where BSE is non-existing. Calmodulin is a calcium-binding protein expressed in many eukaryotic cells. By binding to and regulating various protein targets, it affects cellular processes such as metabolism, nerve growth, apoptosis, inflammation, muscle contraction and memory.

Medicago AB

Applications

  • Protein calcium binding studies on the regulation of a multitude of different protein targets
  • Activation of cyclic nucleotide-dependent phosphodiesterase
  • Co-factor/activator for kinase studies
  • Studies of edema factor toxin and anthrax bacteria

If you cannot find the answer to your problem below then please contact us or telephone 01954 210 200