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Oligo Synthesis

Oligo Synthesis : CEPs

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Palmitate Phosphoramidite

Palmityl-6-aminohexyl [(2-cyanoethyl)-(N,N-diisopropyl)]phosphoramidite

Glen Research

Catalogue No.DescriptionPack SizePriceQty
10-1978-02Palmitate Phosphoramidite0.25g £460.00 Quantity Add to Order
10-1978-90Palmitate Phosphoramidite100µmoles £120.00 Quantity Add to Order
10-1978-95Palmitate Phosphoramidite50µmoles £60.00 Quantity Add to Order

Description

Palmitate Phosphoramidite is a saturated fatty acid with a 16-carbon backbone. This 5’-modification is a lipophilic group. When incorporated into a synthetic oligonucleotide, Palmitate conjugates offer enhanced cellular uptake and delivery to extrahepatic tissues.

Product Specifications

Formula: C31H62N3O3P
M.W.: 555.83
F.W.: 417.57
CAS Number: 1772522-18-5

Usage

  • Coupling: 6 minute coupling time recommended
  • Deprotection: No changes needed from standard method recommended by synthesizer manufacturer.
Specifications
Diluent Anhydrous Acetonitrile/Dichloromethane 1:3 (v/v)
Storage Freezer storage, -10 to -30°C, dry
Stability1-2 Days

 

Dilution/Coupling Data

The table below show pack size data and, for solutions, dilution and approximate coupling based on normal priming procedures.

ABI 392/394

Catalog # Pack Size Grams/Pack 0.1M Dil. (mL) Approximate Number of Additions

LV40 LV200 40nm 0.2μm 1μm 10μm
10-1978-95 50 µmol .028grams 0.5 3.33 2 1.25 0.91 0.67 0.17
10-1978-90 100 µmol .056grams 1 20 12 7.5 5.45 4 1
10-1978-02 0.25 g 0.25grams 4.5 136.67 82 51.25 37.27 27.33 6.83

Expedite

Catalog # Pack Size Grams/Pack Dilution (mL) Approximate Number of Additions

Molarity 50nm 0.2μm 1μm 15μm
10-1978-95E 50 µmol .028grams 0.75 0.07 8.6 5.38 3.91 0.54
10-1978-90E 100 µmol .056grams 1.5 0.07 23.6 14.75 10.73 1.48
10-1978-02E0.25 g0.25grams6.710.07127.879.8858.097.99

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References

References

The Glen Report, 2012, 24.1, 10.

S.K. Pandey, et al., J Pharmacol Exp Ther, 2015, 355, 329-40.

A.E. Chappell, et al., Nucleic Acids Res, 2020, 48, 4382-4395.

K. Relizani, et al., Nucleic Acids Res, 2022, 50, 17-34.

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Notes

Safety Data Sheet

Glen Report 34-16: New Product — Palmitate Phosphoramidite

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Related products

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