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Oligo Synthesis

Oligo Synthesis : CEPs

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2'-OMe-N6-Me-A-CE Phosphoramidite

5'-Dimethoxytrityl-N-methyl-N-phenoxyacetyl-Adenosine,2'-O-methyl- 3'-[(2-cyanoethyl)-(N,N-diisopropyl)]-phosphoramidite

Glen Research

Catalogue No.DescriptionPack SizePriceQty
10-3105-022'-OMe-N6-Me-A-CE Phosphoramidite0.25grams £495.00 Quantity Add to Order
10-3105-902'-OMe-N6-Me-A-CE Phosphoramidite100µmoles £209.00 Quantity Add to Order
10-3105-952'-OMe-N6-Me-A-CE Phosphoramidite50µmoles £118.00 Quantity Add to Order


2’-OMe-N6-Me-A, commonly referred to as m6Am, is a crucial component of the 5’-cap of mRNA. 2’-OMe-A is often the first transcribed nucleotide, and this modification is a result of methylation at the N6-position of the nucleobase. The 5’-cap structures initiate translation and protect RNA from degradation. Internal m6Am, have also been implicated in regulating gene expression, RNA splicing, and cancer proliferation. We offer the 2’-OMe-N6-Me-A RNA monomer with a phenoxyacetyl protecting group to minimize potential branching. 2’-OMe-N6-Me-A-CE Phosphoramidite is compatible with popular synthesis and deprotection methods, from UltraMild to AMA.

Product Specifications


Formula: C50H58N7O9P
M.W.: 932.03
F.W.: 357.28



  • Coupling: 6 minute coupling time. To avoid any exchange of the iPr-Pac group on the G with acetyl, use the UltraMild Cap Mix A (40-4210-xx/ 40-4212-xx).
  • Deprotection: UltraMild deprotection: 0.05M Potassium Carbonate in Methanol, 4 hours at Room Temperature OR 2 hours at Room Temperature in 30% Ammonium Hydroxide.

Dilution/Coupling Data

The table below show pack size data and, for solutions, dilution and approximate coupling based on normal priming procedures.

ABI 392/394

Catalog # Pack Size Grams/Pack 0.1M Dil. (mL) Approximate Number of Additions

LV40 LV200 40nm 0.2μm 1μm 10μm
10-3105-95 50 µmol 0.47 0.5 3.33 2 1.25 0.91 0.67 0.17
10-3105-90 100 µmol 0.93 1 20 12 7.5 5.45 4 1
10-3105-02 0.25 g 0.25 2.68 0 45.6 28.5 20.73 15.2 3.8


Catalog # Pack Size Grams/Pack Dilution (mL) Approximate Number of Additions

Molarity 50nm 0.2μm 1μm 15μm
10-3105-95E 50 µmol 0.47 0.75 0.07 8.6 5.38 3.91 0.54
10-3105-90E 100 µmol 0.93 1.5 0.07 23.6 14.75 10.73 1.48
10-3105-02E 0.25 g 0.25 4 0.07 73.6 46 33.45 4.6


If you cannot find the answer to your problem then please contact us or telephone +44 (0)1954 210 200


Download the following (links to manufacturer's site):


Deprotection information

Glen Report article








If you cannot find the answer to your problem then please contact us or telephone +44 (0)1954 210 200

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If you cannot find the answer to your problem then please contact us or telephone +44 (0)1954 210 200