Cambio - Excellence in Molecular Biology

Aptamers

Aptamers: Catalogue Aptamers

Please remember to pick your Modification from "Related items"

If the listed modifications do not meet your needs many other modifications are available on request

All Aptamers from Base Pair Bio are available with the following modifications

Please choose your modification and add as an extra catalogue number:

 

ATWUNMOD - Unmodified

ATWAMINE - Amine modification

ATWBIOTIN - Biotin modification

ATWTHIOL - Thiol modification (extra charge)

ATWFLUOR - Fluor (all) modification (extra charge)

 

Interleukin 6 (IL6) Aptamer to Murine Protein Target

IL6 (mu) - sandwich pair ATW0077

Base Pair Bio

Catalogue No.DescriptionPack SizePriceQty
ATW0077-100IL6 (mu) 10 AEU (100ug) POA Quantity Add to Order
ATW0077-25IL6 (mu) 2.5 AEU (25ug) POA Quantity Add to Order

Interleukin 6 (IL6) Aptamer to Murine Protein Target

IL6 (mu) - sandwich pair ATW0077

Base Pair Bio

Interleukin 6 (IL6) is an interleukin that acts as both a pro-inflammatory and anti-inflammatory cytokine. It is secreted by T cells and macrophages to stimulate immune response and is also considered a "myokine," a cytokine produced from muscle, and is elevated in response to muscle contraction. It is significantly elevated with exercise, and precedes the appearance of other cytokines in the circulation. During exercise, it is thought to act in a hormone-like manner to mobilize extracellular substrates and/or augment substrate delivery. Additionally, osteoblasts secrete IL6 to stimulate osteoclast formation. Smooth muscle cells in the tunica media of many blood vessels also produce IL6 as a pro-inflammatory cytokine. IL6's role as an anti-inflammatory cytokine is mediated through its inhibitory effects on TNF-alpha and IL1, and activation of IL1ra and IL10.

Target:   IL-6 (Interleukin-6)

Target Species:   murine

Target Type:   protein

Affinity Constant (Kd):   5.4 nM

Default 3' Linker (Spacer) is 10T. Please submit a custom quote request for other options.

This aptamer was selected by scientists at Base Pair Biotechnologies using proprietary methods, recombinant Murine Interleukin 6, [BioLegend Cat# 575706] and 1X PBS, pH = 7.4. ATW0077 is a sandwich pair with ATW0082 and ATW0083.   Let us know if you have any questions about its development or potential uses.

Aptamer information Kd 7.4 ± 1.7 nM

IL6 ATW0077.ATW0082 #EALRN#D92GX  datasheet

IL6 ATW0077.ATW0083 #EALRN#D95W1  datasheet

 

Please choose your modification and add as an extra catalogue number:
ATWUNMOD - Unmodified
ATWAMINE - Amine modification
ATWBIOTIN - Biotin modification
ATWTHIOL - Thiol modification (extra charge)
ATWFLUOR - Fluor (all) modification (extra charge)

If you cannot find the answer to your problem below then please contact us or telephone 01954 210 200

Interleukin 6 (IL6) Aptamer to Murine Protein Target

IL6 (mu) - sandwich pair ATW0077

Base Pair Bio

Antibody Equivalent Units (AEU).  There is a  large molecular weight difference in antibodies (typically 150,000 Da) and Base Pair’s aptamers (~14,000 Da).   We provide our aptamers in terms of moles, where the aptamer moles in 1  AEU is equal to antibody moles in the typical 100 microgram shipment from a leading antibody vendor. Therefore our standard 2.5 AEU (25ug) or 5 AEU (50ug) delivery is 2.5 and 5 times the equivalent moles of a standard antibody delivery of 100 microgram respectively

If you cannot find the answer to your problem below then please contact us or telephone 01954 210 200