Cambio - Excellence in Molecular Biology

Aptamers

Aptamers: Catalogue Aptamers

Important information

Do you know what modifications you will need for your aptamers?  see "modifications" section for details

CD63

Recombinant CD63 human protein ATW0057

Base Pair Bio

Catalogue No.DescriptionPack SizePriceQty
  • Change to:
  • £
ATW0057-100CD6310 AEU (100ug) POA Quantity Add to Order
ATW0057-25CD632.5 AEU (25ug) POA Quantity Add to Order

Description

CD63 is a tetraspanin, a cell surface-associated membrane protein with four transmembrane domains. CD63 interacts with integrins, cell surface receptors, kinases, and many other proteins. Cell surface expression of CD63 is highly regulated. While CD63 is involved with HIV-1 entry into T-lymphocytes, decreased surface expression of CD63 is associated with an increase in cancer invasiveness and metastasis.

Target:   CD63

Target Species:   human

Target Type:   protein

Affinity Constant (Kd):   29.9 nM

Default 3' Linker (Spacer) is 10T. Please submit a custom quote request for other options.

Aptamer was selected at Base Pair Biotechnologies from a randomized 32-mer DNA library against human CD63 protein. Proprietary methods were then used to select the aptamer.

DataSheet

0.1uM synthesis scale (20-200ug)
Please choose your modification and add as an extra catalogue number:
ATWUNMOD - Unmodified
ATWAMINE - Amine modification
ATWBIOTIN - Biotin modification
ATWTHIOL - Thiol modification (extra charge)
ATWFLUOR - Fluor (all) modification (extra charge)


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Protocols

DataSheet

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References

Pols, M.S., et al. (2009) Trafficking and function of the tetraspanin CD63. Exp Cell Res. , 15,315(9):1584-92.

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Notes

Please note that aptamers have much lower molecular weights than antibodies. Thus, there are typically five to fifteen times as many moles or molecules of aptamers present in a solution containing an equal mass. For example, 100 micrograms of an aptamer is equivalent to 0.5 to 1.5 mg of antibody, depending on the particular aptamer.

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Related products

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