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Oligo Synthesis

Oligo Synthesis : Supports,CPGs

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3'-Cholesteryl-TEG CPG

3'-Cholesteryl-TEG CPG

Glen Research

Catalogue No.DescriptionPack SizePriceQty
20-2975-013'-Cholesteryl-TEG CPG 0.1g £68.00£62.56Offer until : 31-Dec-2019Offer Code : GLEN88% off all Glen Research products View Offer Quantity Add to Order
20-2975-103'-Cholesteryl-TEG CPG 1.0g £560.00£515.20Offer until : 31-Dec-2019Offer Code : GLEN88% off all Glen Research products View Offer Quantity Add to Order
20-2975-133'-Cholesteryl-TEG CPG 1x10µm £168.00£154.56Offer until : 31-Dec-2019Offer Code : GLEN88% off all Glen Research products View Offer Quantity Add to Order
20-2975-143'-Cholesteryl-TEG CPG 1x15µm £252.00£231.84Offer until : 31-Dec-2019Offer Code : GLEN88% off all Glen Research products View Offer Quantity Add to Order
20-2975-413'-Cholesteryl-TEG CPG 4x1.0µm £112.00£103.04Offer until : 31-Dec-2019Offer Code : GLEN88% off all Glen Research products View Offer Quantity Add to Order
20-2975-423'-Cholesteryl-TEG CPG 4x0.2µm £67.20£61.82Offer until : 31-Dec-2019Offer Code : GLEN88% off all Glen Research products View Offer Quantity Add to Order

3'-Cholesteryl-TEG CPG

3'-Cholesteryl-TEG CPG

Glen Research

3'-Cholesteryl-TEG CPG

Structure

Catalog Number: 20-2975-xx

Description: 3'-Cholesteryl-TEG CPG

1-Dimethoxytrityloxy-3-O-(N-cholesteryl-3-aminopropyl)-triethyleneglycol-
glyceryl-2-O-succinoyl-long chain alkylamino-CPG


F.W.: 755.97

Diluent: Not Applicable
Coupling: This support should be used in a manner identical to normal protected nucleoside support since it contains the DMT group.
Deprotection: Cleavage of the oligonucleotide from this support requires 2 hours at room temperature with ammonium hydroxide. Complete the deprotection using the protocol required by the nucleobases.
Storage: Freezer storage, -10 to -30°C, dry
Stability in Solution: Not Applicable

CHOLESTEROL LABELLING

Potential therapeutic oligonucleotides must permeate the cell membrane for optimal activity. The addition of lipophilic groups to an oligonucleotide would be expected to enhance activity. The use of cholesteryl oligos and the consequent improvement in activity has been described. We have designed our Cholesteryl Phosphoramidite with our branched triethyleneglycol (TEG) spacer for maximum solubility in acetonitrile as well as for applications requiring multiple labels.

 

ABI-style vials and columns are supplied unless otherwise requested (see note box).

If you cannot find the answer to your problem below then please contact us or telephone 01954 210 200

3'-Cholesteryl-TEG CPG

3'-Cholesteryl-TEG CPG

Glen Research

MSDS

Glen Report 7.1

If you cannot find the answer to your problem below then please contact us or telephone 01954 210 200