Interleukin-18 (IL-18) is a cytokine
that belongs to the IL-1 superfamily and is produced by macrophages and
other cells. IL-18 works by binding to the interleukin-18 receptor, and
together with IL-12 it induces cell-mediated immunity following
infection with microbial products like lipopolysaccharide (LPS). After
stimulation with IL-18, natural killer (NK) cells and certain T cells
release another important cytokine called interferon-γ (IFNγ) or type II
interferon that plays an important role in activating the macrophages
or other cells.
This aptamer was selected by scientists at Base Pair
Biotechnologies using proprietary methods and human Interleukin-18.
[Novus Biologicals, Cat #NBC1-20152]
Target: IL-18 (Interleukin-18)
Target Species: human
Target Type: protein
Affinity Constant (Kd): 20.4 nM
Default 3' Linker (Spacer) is 10T. Please submit a custom quote request for other options.
Datasheet protocol
0.1uM synthesis scale (20-200ug)
Please choose your modification and add as an extra catalogue number:
ATWUNMOD - Unmodified
ATWAMINE - Amine modification
ATWBIOTIN - Biotin modification
ATWTHIOL - Thiol modification (extra charge)
ATWFLUOR - Fluor (all) modification (extra charge)
If you cannot find the answer to your problem then please contact us or telephone +44 (0)1954 210 200